The PRECISE (PREgnancy Care Integrating translational Science, Everywhere) Network is an interdisciplinary group of research scientists and health advocates from sub-Saharan Africa, Europe, Canada and the USA, that is investigating the origins and outcomes of the placental disorders in sub-Saharan Africa. Funded by the UK Research and Innovation Global Challenges Research Fund (GCRF), PRECISE aims to develop a robust clinic-based research infrastructure, database and biobank that will catalyse formative research, describe the pathways to placental disorders and their complications in sub-Saharan Africa, and inform the design of effective interventions. Importantly, this programme will provide essential information about the impact of placental disorders on women’s lives and their communities.

The five papers in this supplement introduce the scientific scope and vision of this ambitious programme of work and describe the development of key components of PRECISE: the study protocol, clinical database, biorepository, qualitative work plans, and partnership and capacity-building elements. The first three papers describe the design of the prospective pregnancy cohort study and the research platform to collect epidemiological data and biological samples from approximately 10,000 pregnant Gambian, Kenyan and Mozambican women. In addition, we will recruit 1800 non-pregnant women of reproductive age as a control group to provide representative regional data and biological samples. The fourth paper in the series describes the value of qualitative research in helping to understand quantitative and biological data. The fifth paper in the series brings the picture of the PRECISE Network together with capacity-building in research infrastructure, strengthening emerging leaders in reproductive science and supporting advocacy for research.

The supplement has been published in BMC reproductive health.

“I am so very proud to be the PI of the PRECISE Network, an alignment of colleagues and friends. These series of papers clarify our activities, skills and potential” Peter von Dadelszen, Principal Investigator.

We hope this supplement will be useful for those who are setting up a similar project elsewhere to help navigate the challenges faced and to learn from our experiences. As well as this, the supplement gives an overview of what we hope to achieve. We are a consortium who are open to collaboration, the clinical data and biorepository are open to researchers who are keen to utilise this resource, therefore we hope this gives an overview of what is available to the wider scientific community.